Preeclampsia and Soluble fms-Like Tyrosine Kinase 1
نویسندگان
چکیده
منابع مشابه
Soluble Fms-Like Tyrosine Kinase-1 Alters Cellular Metabolism and Mitochondrial Bioenergetics in Preeclampsia
Preeclampsia is a maternal hypertensive disorder that affects up to 1 out of 12 pregnancies worldwide. It is characterized by proteinuria, endothelial dysfunction, and elevated levels of the soluble form of the vascular endothelial growth factor receptor-1 (VEGFR-1, known as sFlt-1). sFlt-1 effects are mediated in part by decreasing VEGF signaling. The direct effects of sFlt-1 on cellular metab...
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Preeclampsia is a hypertensive disorder of pregnancy in which patients develop profound sensitivity to vasopressors, such as angiotensin II, and is associated with substantial morbidity for the mother and fetus. Enhanced vasoconstrictor sensitivity and elevations in soluble fms-like tyrosine kinase 1 (sFLT1), a circulating antiangiogenic protein, precede clinical signs and symptoms of preeclamp...
متن کاملPilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia.
BACKGROUND Targeted therapies to stabilize the clinical manifestations and prolong pregnancy in preeclampsia do not exist. Soluble fms-like tyrosine kinase 1 (sFlt-1), an alternatively spliced variant of the vascular endothelial growth factor receptor 1, induces a preeclampsia-like phenotype in experimental models and circulates at elevated levels in human preeclampsia. Removing sFlt-1 may bene...
متن کاملPrediction of Preeclampsia Using the Soluble fms-Like Tyrosine Kinase 1 to Placental Growth Factor Ratio
We sought to assess the ratio of sFlt-1 (soluble fms-like tyrosine kinase 1) to PlGF (placental growth factor) in maternal serum as a screening test for preeclampsia in unselected nulliparous women with a singleton pregnancy. We studied 4099 women recruited to the POP study (Pregnancy Outcome Prediction) (Cambridge, United Kingdom). The sFlt-1:PlGF ratio was measured using the Roche Cobas e411 ...
متن کاملDifferential diagnosis of preeclampsia: remember the soluble fms-like tyrosine kinase 1/placental growth factor ratio.
P reeclampsia is a pregnancy-associated condition, clinically characterized by hypertension, proteinuria, and progressive edema, affecting 3% to 5% of all pregnancies. 1 Preeclampsia can occur in previously healthy women and in women with underlying conditions, such as hypertension, lupus nephri-tis, or the antiphospholipid syndrome (APS). 1,2 Conversely, pregnancy can be a trigger to activate ...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2009
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2009-0945